Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis
نویسندگان
چکیده
BACKGROUND Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma. OBJECTIVE To investigate the associations between Staphylococcal enterotoxin sensitization and asthma. METHODS A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization. RESULTS A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82). CONCLUSION Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.
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